This commit re-implements several critical physiological feedback loops that were lost, enhancing the realism of the simulation.
The following systems have been added:
1. **Full Digestive Loop:**
- The Gallbladder now has a `releaseBile` method, triggered by chyme in the intestines.
- The Pancreas has a `releaseEnzymes` method, also triggered by chyme.
- The Intestines' digestion logic has been updated to be more effective when bile and enzymes are present.
2. **Autonomic Nervous System Control:**
- The Brain now monitors blood gas (O2/CO2) and blood pressure levels.
- It dynamically adjusts the respiration rate of the Lungs via a new `setRespirationRate` method in response to blood gas changes.
- It controls the heart rate via a new `setHeartRate` method in response to blood pressure changes, simulating the baroreceptor reflex.
- The previous hardcoded rate control logic in the Lungs and Heart has been removed.
3. **Kidney Blood Pressure Regulation (RAAS):**
- A simplified Renin-Angiotensin-Aldosterone System has been implemented.
- The Kidneys now secrete renin in response to low blood pressure.
- The Liver produces a constant supply of angiotensinogen.
- A new `angiotensin_au` value in the Blood struct is calculated in the main patient update loop.
- This hormone now acts as a vasoconstrictor, directly affecting the blood pressure calculation in the Heart.
These changes significantly increase the complexity and fidelity of the medical simulation by modeling the interconnectedness of the major organ systems.
This commit refactors the organ simulation to enable dynamic interactions between organs, replacing the previous "faked" or hardcoded connections.
Key changes include:
- Major Refactoring: Changed the `Organ::update` method signature to `update(Patient& patient, double deltaTime_s)`, allowing organs to access the shared patient state and other organs. This was propagated to all organ classes.
- Blood Chemistry Model: Introduced a central `Blood` struct in the `Patient` model to track shared resources like oxygen, CO2, glucose, and toxins.
- Organ System Interconnections:
- Lungs & Brain: Lungs now perform gas exchange affecting the blood. The brain consumes O2, produces CO2, and its GCS is affected by hypoxia/hypercapnia.
- Liver-Gallbladder: Gallbladder now receives bile directly from the liver's production rate.
- Digestive System: Stomach passes chyme to the intestines, which absorb glucose into the blood. The pancreas responds to blood glucose changes.
- Renal System: Kidneys' GFR is now influenced by the heart's aortic pressure, and they produce urine that fills the bladder directly.
- Cardiovascular & Neurological: The heart rate responds to hypoxia, and the brain uses live aortic pressure from the heart.
- Comprehensive Test Scenario: Updated the main example to include a 60-second simulation with a meal and a lung injury event to verify the new interconnected system.
This creates a more realistic and scalable physiological simulation framework where organ behaviors are emergent from their interactions.
Applied the level of detail from the Heart simulation to the Lungs and Brain classes.
For the Lungs:
- Added anatomical structures for lobes and bronchi.
- Implemented a respiratory cycle with inspiration/expiration states.
- Simulated tidal volume, airway pressures, and gas exchange.
- Generated a capnography (etCO2) waveform.
For the Brain:
- Added structures for major brain regions.
- Simulated intracranial pressure (ICP) and cerebral perfusion pressure (CPP).
- Implemented a simplified Glasgow Coma Scale (GCS).
- Generated a basic EEG waveform.
This commit significantly expands the patient simulation by adding models
for the full digestive and urinary systems, as well as the spleen and
spinal cord.
This builds on the polymorphic organ framework by adding 9 new organ
classes:
- Kidneys
- Bladder
- Stomach
- Intestines
- Gallbladder
- Pancreas
- Esophagus
- Spleen
- SpinalCord
Each new organ has its own header, a source file with simplified
simulation logic for its unique physiological properties, and is
integrated into the main patient model and simulation loop.
The build system and example application have been updated to include
and demonstrate this new, more comprehensive set of organs.
google-labs-jules[bot]