diff --git a/src/apps/chat/components/StatusBar.tsx b/src/apps/chat/components/StatusBar.tsx
index ab68ed0e7..b618d3aad 100644
--- a/src/apps/chat/components/StatusBar.tsx
+++ b/src/apps/chat/components/StatusBar.tsx
@@ -10,6 +10,7 @@ import { ShortcutKey, ShortcutObject } from '~/common/components/shortcuts/useGl
 import { ConfirmationModal } from '~/common/components/modals/ConfirmationModal';
 import { GoodTooltip } from '~/common/components/GoodTooltip';
 import { useGlobalShortcutsStore } from '~/common/components/shortcuts/store-global-shortcuts';
+import { useShortcutsPreferencesStore, shortcutFingerprint } from '~/common/components/shortcuts/store-shortcuts-preferences';
 import { useOverlayComponents } from '~/common/layout/overlays/useOverlayComponents';
 import { useUXLabsStore } from '~/common/stores/store-ux-labs';
 
@@ -176,9 +177,12 @@ export function StatusBar(props: { toggleMinimized?: () => void, isMinimized?: b
 
   // external state
   const labsShowShortcutBar = useUXLabsStore(state => state.labsShowShortcutBar);
+  const disabledShortcuts = useShortcutsPreferencesStore(state => state.disabledShortcuts);
   const shortcuts = useGlobalShortcutsStore(useShallow(state => {
-    // get visible shortcuts
-    let visibleShortcuts = !labsShowShortcutBar ? [] : state.getAllShortcuts().filter(shortcut => !!shortcut.description);
+    // get visible shortcuts, excluding user-denied ones
+    let visibleShortcuts = !labsShowShortcutBar ? [] : state.getAllShortcuts().filter(shortcut =>
+      !!shortcut.description && !disabledShortcuts.includes(shortcutFingerprint(shortcut)),
+    );
 
     // filter by highest level if levels are present
     const maxLevel = Math.max(...visibleShortcuts.map(s => s.level ?? 0));
diff --git a/src/apps/chat/components/composer/Composer.tsx b/src/apps/chat/components/composer/Composer.tsx
index 7b51702b8..d9a16bdcb 100644
--- a/src/apps/chat/components/composer/Composer.tsx
+++ b/src/apps/chat/components/composer/Composer.tsx
@@ -26,6 +26,7 @@ import { ConversationsManager } from '~/common/chat-overlay/ConversationsManager
 import { DMessageId, DMessageMetadata, DMetaReferenceItem, messageFragmentsReduceText } from '~/common/stores/chat/chat.message';
 import { PhPaintBrush } from '~/common/components/icons/phosphor/PhPaintBrush';
 import { ShortcutKey, ShortcutObject, useGlobalShortcuts } from '~/common/components/shortcuts/useGlobalShortcuts';
+import { isShortcutDenied } from '~/common/components/shortcuts/store-shortcuts-preferences';
 import { addSnackbar } from '~/common/components/snackbar/useSnackbarsStore';
 import { animationEnterBelow } from '~/common/util/animUtils';
 import { browserSpeechRecognitionCapability, PLACEHOLDER_INTERIM_TRANSCRIPT, SpeechResult, useSpeechRecognition } from '~/common/components/speechrecognition/useSpeechRecognition';
@@ -545,16 +546,20 @@ export function Composer(props: {
 
       // Alt (Windows) or Option (Mac) + Enter: append the message instead of sending it
       if (e.altKey && !e.metaKey && !e.ctrlKey) {
-        if (await handleSendAction('append-user', composeText)) // 'alt+enter' -> write
-          e.stopPropagation();
-        return e.preventDefault();
+        if (!isShortcutDenied({ key: 'Enter', alt: true })) {
+          if (await handleSendAction('append-user', composeText)) // 'alt+enter' -> write
+            e.stopPropagation();
+          return e.preventDefault();
+        }
       }
 
       // Ctrl (Windows) or Command (Mac) + Enter: send for beaming
       if (e.ctrlKey && !e.metaKey && !e.altKey) {
-        if (await handleSendAction('beam-content', composeText)) // 'ctrl+enter' -> beam
-          e.stopPropagation();
-        return e.preventDefault();
+        if (!isShortcutDenied({ key: 'Enter', ctrl: true })) {
+          if (await handleSendAction('beam-content', composeText)) // 'ctrl+enter' -> beam
+            e.stopPropagation();
+          return e.preventDefault();
+        }
       }
 
       // Shift: toggles the 'enter is newline'
diff --git a/src/apps/settings-modal/ShortcutsModal.tsx b/src/apps/settings-modal/ShortcutsModal.tsx
index 925f0c383..63c27617d 100644
--- a/src/apps/settings-modal/ShortcutsModal.tsx
+++ b/src/apps/settings-modal/ShortcutsModal.tsx
@@ -1,10 +1,13 @@
 import * as React from 'react';
 
-import { Box, Chip, Divider, Typography } from '@mui/joy';
+import { Box, Chip, Divider, IconButton, Tooltip, Typography } from '@mui/joy';
+import BlockIcon from '@mui/icons-material/Block';
+import CheckCircleOutlineIcon from '@mui/icons-material/CheckCircleOutline';
 
 import { GoodModal } from '~/common/components/modals/GoodModal';
 import type { ShortcutDefinition } from '~/common/components/shortcuts/useGlobalShortcuts';
 import { shortcutsCatalog } from '~/common/components/shortcuts/shortcutsCatalog';
+import { shortcutFingerprint, useShortcutsPreferencesStore } from '~/common/components/shortcuts/store-shortcuts-preferences';
 import { useGlobalShortcutsStore } from '~/common/components/shortcuts/store-global-shortcuts';
 import { useIsMobile } from '~/common/components/useMatchMedia';
 import { Is } from '~/common/util/pwaUtils';
@@ -36,6 +39,11 @@ const _styles = {
     justifyContent: 'space-between',
     gap: 1,
   },
+  rowLeft: {
+    display: 'flex',
+    alignItems: 'center',
+    gap: 1,
+  },
   keys: {
     display: 'flex',
     gap: 0.5,
@@ -111,6 +119,42 @@ function ShortcutKeyCombo(props: { def: ShortcutDefinition }) {
 }
 
 
+function ShortcutRow(props: { item: typeof shortcutsCatalog[number]['items'][number], active: boolean }) {
+  const { item, active } = props;
+
+  const fp = shortcutFingerprint(item);
+  const isDenied = useShortcutsPreferencesStore((state) => state.disabledShortcuts.includes(fp));
+
+  const handleToggle = React.useCallback(() => {
+    useShortcutsPreferencesStore.getState().toggleShortcutDisabled(fp);
+  }, [fp]);
+
+  const effectivelyActive = active && !isDenied;
+
+  return (
+    <Box sx={_styles.row}>
+      <Box sx={_styles.rowLeft}>
+        <Tooltip title={isDenied ? 'Enable shortcut' : 'Disable shortcut'} variant='soft'>
+          <IconButton
+            size='sm'
+            variant={isDenied ? 'soft' : 'plain'}
+            color={isDenied ? 'danger' : 'neutral'}
+            onClick={handleToggle}
+            sx={{ minWidth: 28, minHeight: 28 }}
+          >
+            {isDenied ? <BlockIcon sx={{ fontSize: 16 }} /> : <CheckCircleOutlineIcon sx={{ fontSize: 16, opacity: 0.5 }} />}
+          </IconButton>
+        </Tooltip>
+        <ShortcutKeyCombo def={item} />
+      </Box>
+      <Typography level='body-xs' sx={!effectivelyActive ? { opacity: 0.5, textDecoration: isDenied ? 'line-through' : undefined } : undefined}>
+        {item.description}
+      </Typography>
+    </Box>
+  );
+}
+
+
 export function ShortcutsModal(props: { onClose: () => void }) {
 
   // external state
@@ -130,14 +174,7 @@ export function ShortcutsModal(props: { onClose: () => void }) {
             </Typography>
             {category.items.map((item, i) => {
               const active = _isActive(item, activeFingerprints);
-              return (
-                <Box key={i} sx={_styles.row}>
-                  <ShortcutKeyCombo def={item} />
-                  <Typography level='body-xs' sx={!active ? { opacity: 0.5 } : undefined}>
-                    {item.description}
-                  </Typography>
-                </Box>
-              );
+              return <ShortcutRow key={i} item={item} active={active} />;
             })}
           </React.Fragment>
         ))}
diff --git a/src/common/components/shortcuts/globalShortcutsHandler.ts b/src/common/components/shortcuts/globalShortcutsHandler.ts
index 355e83507..9319c545b 100644
--- a/src/common/components/shortcuts/globalShortcutsHandler.ts
+++ b/src/common/components/shortcuts/globalShortcutsHandler.ts
@@ -1,4 +1,5 @@
 import { useGlobalShortcutsStore } from './store-global-shortcuts';
+import { isShortcutDenied } from './store-shortcuts-preferences';
 
 
 export function ensureGlobalShortcutHandler() {
@@ -41,6 +42,10 @@ function _handleGlobalShortcutKeyDown(event: KeyboardEvent) {
     if (shortcut.skipIfInput && _isTextInputFocused())
       continue;
 
+    // Skip if the shortcut is on the user's denylist
+    if (isShortcutDenied(shortcut))
+      continue;
+
     // Execute the action (and prevent the default browser action)
     event.preventDefault();
     event.stopPropagation();
diff --git a/src/common/components/shortcuts/store-shortcuts-preferences.ts b/src/common/components/shortcuts/store-shortcuts-preferences.ts
new file mode 100644
index 000000000..230ae312e
--- /dev/null
+++ b/src/common/components/shortcuts/store-shortcuts-preferences.ts
@@ -0,0 +1,43 @@
+import { create } from 'zustand';
+import { persist } from 'zustand/middleware';
+
+import type { ShortcutDefinition } from './useGlobalShortcuts';
+
+
+export function shortcutFingerprint(def: Pick<ShortcutDefinition, 'key' | 'ctrl' | 'shift' | 'alt'>): string {
+  return `${def.key.toLowerCase()}:${!!def.ctrl}:${!!def.shift}:${!!def.alt}`;
+}
+
+
+interface ShortcutsPreferencesStore {
+  disabledShortcuts: string[];
+  toggleShortcutDisabled: (fingerprint: string) => void;
+}
+
+export const useShortcutsPreferencesStore = create<ShortcutsPreferencesStore>()(
+  persist(
+    (set) => ({
+
+      disabledShortcuts: [],
+
+      toggleShortcutDisabled: (fingerprint: string) =>
+        set((state) => {
+          const idx = state.disabledShortcuts.indexOf(fingerprint);
+          if (idx >= 0)
+            return { disabledShortcuts: state.disabledShortcuts.filter((f) => f !== fingerprint) };
+          return { disabledShortcuts: [...state.disabledShortcuts, fingerprint] };
+        }),
+
+    }),
+    {
+      name: 'app-shortcuts-preferences',
+      version: 1,
+    },
+  ),
+);
+
+
+export function isShortcutDenied(def: Pick<ShortcutDefinition, 'key' | 'ctrl' | 'shift' | 'alt'>): boolean {
+  const fp = shortcutFingerprint(def);
+  return useShortcutsPreferencesStore.getState().disabledShortcuts.includes(fp);
+}