diff --git a/src/proxy/middleware/response/index.ts b/src/proxy/middleware/response/index.ts
index ae19a6c..540c208 100644
--- a/src/proxy/middleware/response/index.ts
+++ b/src/proxy/middleware/response/index.ts
@@ -274,6 +274,12 @@ const handleUpstreamErrors: ProxyResHandlerWithBody = async (
         assertNever(service);
     }
   } else if (statusCode === 401) {
+    // OpenAI specific - retry with different key for any 401 error
+    if (service === "openai") {
+      keyPool.disable(req.key!, "revoked");
+      await reenqueueRequest(req);
+      throw new RetryableError("OpenAI key authentication failed, retrying with different key.");
+    }
     // Key is invalid or was revoked
     keyPool.disable(req.key!, "revoked");
     errorPayload.proxy_note = `Assigned API key is invalid or revoked, please try again.`;
@@ -281,6 +287,7 @@ const handleUpstreamErrors: ProxyResHandlerWithBody = async (
     // Deepseek specific - insufficient balance
     if (service === "deepseek") {
       keyPool.disable(req.key!, "quota");
+      await reenqueueRequest(req);
       throw new RetryableError("Deepseek key has insufficient balance, retrying with different key.");
     }
   } else if (statusCode === 405) {